W-10Ti alloy was prepared，and the effects of cold isostatic pressing （CIP） pressure， hot isostatic pressing （HIP） temperature and high temperature treatment on the microstructure are studied.It is found that CIP can significantly increase the charge density，which is beneficial to HIP forming and element diffusion. The diffusion of W and Ti can be improved by increasing CIP pressure and HIP temperature.At HIP1 300 ℃， pure Ti phase is completely eliminated.When the high temperature treatment temperature is 1 300，1 400，1 500 and 1 700 ℃，the content of Ti-rich phase decreases first and then increases， and reaches the lowest at 1 400 ℃， which is 5.18%.When treated at more than 1 400 ℃，the Ti-rich phase underwent eutectoid transformation.