In the assembly process of aircraft parts， the connection of CFRP/ titanium alloy laminated structure is very common. Due to the very different material properties of the two materials， the pore size order difference exists after hole making， which seriously affects the fatigue strength of CFRP/ titanium alloy structure. In this paper， the orthogonal experiment of low-frequency vibration-assisted drilling was carried out， and the relationship between the technological parameters of low-frequency vibration-assisted drilling and the cutting force and chip morphology was analyzed， as well as the influence of technological parameters on the pore size difference of CFRP/ titanium alloy. The results show that titanium alloy chips change from long continuous chips to short sector chips due to the periodic feed of low frequency vibration-assisted drilling tool， cutting heat in drilling area decreases and average axial force decreases. In addition， the influence of amplitude and feed on the aperture order difference is relatively significant， while the influence of spindle speed is relatively small. Moreover， the aperture order difference first decreases and then increases with the increase of amplitude， and then increases with the increase of feed. Through test verification and analysis， the optimal process parameter combination scheme for aperture control-oriented is determined： spindle speed is 600 r/min， feed is 0.02mm/r， and amplitude is 150 μm.